5-Fluorouracil

5‑Fluorouracil (5‑FU)

Basic Information:

• CAS Number: 51‑21‑8
• Molecular Formula: C₄H₃FN₂O₂
• Molecular Weight: 130.08 g/mol
• Appearance: White to nearly white crystalline powder, practically odorless
• Melting point: ~282‑286 °C (decomposes)
• Density: ~1.45 g/cm³
• Solubility: Soluble in DMF, DMSO, methanol, ethanol, hot water
• Pack Size: 100g
• Product No: F809394

Uses & Function:

• Potent antitumor (antineoplastic) agent used in chemotherapy
• Inhibits thymidylate synthase, disrupting DNA synthesis
• Clinically used for breast, colorectal, anal, gastric, pancreatic, and skin cancers

Safety & Hazard Information:

• Signal word: Danger
• Hazard classifications: Acute toxicity, carcinogenicity, mutagenicity, reproductive toxicity
• Hazard statements: Toxic if swallowed; may cause serious eye and skin irritation; may damage fertility or the unborn child; may cause genetic defects

Exposure & Health Effects:

• Toxicity: LD₅₀ (oral, rabbit) ~230 mg/kg
• Can cause bone marrow suppression, nausea, vomiting, and other systemic effects
• Harmful if swallowed, inhaled, or in contact with skin

Handling & Storage:

• Use appropriate PPE: gloves, lab coat, eye protection
• Store cool and protected from light
• Avoid release to the environment and contact with oxidizing agents